DISSOLUTION TEST METHOD AND HPLC ANALYSIS FOR LANSOPRAZOLE PELLETS DOSAGE FORMS

Authors

  • Venkanna. R Assistant Professor, Department of chemistry, K.G Reddy Engineering College and Technology, Hyderabad-501504
  • Srinivasarao. Tumati Assistant Professor, Department of chemistry, K.G Reddy Engineering College and Technology, Hyderabad-501504
  • A. Revathi Assistant Professor, Department of chemistry, K.G Reddy Engineering College and Technology, Hyderabad-501504

Keywords:

Dissolution test, HPLC, Lansoprazole Pellets dosage forms, RPM, Mobile phase

Abstract

A Simple dissolution test procedure for Lansoprazole pellets dosages has been proposed and high performance liquid chromatography analytical method was developed for the measurement of Lansoprazole Pellets dosage forms with U.V detection. The chromatographic system consisted of a Zodiac ODS 4.6mm× 150mm column, an isocratic mobile phase of 650ml phosphate buffer+350ml acetonitrile. The flow rate is 1ml /minute and effluent is tested at 286nm, The lansoprazole was eluted at about 5.681min with no interfering peak from additives used for preparation dosage form. The method was linear over the range of 10-150µg/ml
lansoprazole. The dissolution test was conducted in 500ml phosphate buffer pH7.6 with paddle stirring at 100 rotation per minute (RPM).Dissolution was found to be not less than 75% in 45 minutes. The proposed method was applied successfully for the measurement of Lansoprazole content in Pellets and for vitro dissolution studies.

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Published

2018-08-22

How to Cite

R, V., Tumati, S., & Revathi, A. (2018). DISSOLUTION TEST METHOD AND HPLC ANALYSIS FOR LANSOPRAZOLE PELLETS DOSAGE FORMS. International Journal of Technical Innovation in Modern Engineering & Science, 4(8), 904–906. Retrieved from https://www.ijtimes.com/index.php/ijtimes/article/view/1082

Issue

Vol. 4 No. 8 (2018): Vol. 4 No. 8: Volume 4 Issue 8 (August-2018)

Section

Articles